This is my take on sorting out the issues in order of mostly likely culprits:
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Intake manifold - With 75K miles, if it is the original manifold, 99% likely you will need to change it out. (I had to replace mine.)
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Dirty valves - Valves will most likely need to have the carbon cleaned off of them. (I did this when I changed the manifold.)
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Spark Plugs and or Coils - Car may need new plugs and new coils. Also, check the coil connectors. If there are any broken connectors, then they probably are not making good contact and can cause misfires. (I replace all my plugs just in case. Coils seemed good so left those alone. I had to replace 4 of the connectors.)
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Vacuum leaks - Look for any damaged hoses and vacuum lines. Can definitely make the car run rough. Its a good idea to replace the valve cover gaskets too. While bad gaskets can leak oil, a bigger problem is that they are a potential source of vacuum leaks.
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Injectors - Failing injectors on these cars a known common cause of misfires. (I did not replace mine but will do this next year as preventative maintenance).
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High Pressure Fuel Pump - Seems to be pretty rare to fail but they can (I had one fail about 2 weeks after I purchased my 2008 with 71K miles. I changed out both.)
I purchased my 2008 almost three months ago and I did #'s 1-4 and 6. I did not replace my injectors as I was at the limit of my budget for repairs but I will do them next year. I also replaced a the PCV hose that connects the valve covers at the back of the engine to the oil separator. Also, replaced the oil separator.
I want to emphasize how important it is to make sure the engine does not have vacuum is. This can cause rough running and misfires. Also, any vacuum leak will cause the car to run lean. This causes the ECM’s to compensate by adding extra fuel. If this condition goes on for a while, it can kill your catalytic converters and your O2 sensors.
Luckily, the V10 seems to only have these things as common issues. Once you are through them, the car is reliable.
Mine has been trouble free for almost 2 months now.