Are you planning on supercharging the car?
I have quite a bit of experience with water and/or methanol injection, albeit, all with turbo powered cars. The Aquamist systems are top notch (I have one for sale btw ;)) and there are gains to be had using them or any other properly setup system. The gains will be relatively minor with an N/A application but there is nothing but benefits from lowering intake temps as you will be able to run more timing, though there is a limit.
If you are going to inject water, you need to make sure your ignition system is up to the task. Granted, in N/A form, you won’t be injecting near as much as FI cars, but it could still challenge your ignition system. Also, meth is highly corrosive and you need to make sure your fuel system can run it. From your pump, lines and fittings to your injectors. All need to be compatible. Many newer cars are capable right out of the box due to “Flex Fuel” e85 options but I am not sure about these cars, especially given their age. Something you would definitely need to look into.
Is it worth the time and expense? I’d only consider it after I’ve done all the other simple bolt-ons so as to maximize its potential.
I am not very familiar with the Audi ecu but it does seem pretty flexible. In any case, the Aquamist system is a standalone setup that works independently of the cars main ecu so that won’t be an issue. Only question is whether the Audi ecu can adjust the tune accordingly to water and/or meth. My guess is that it can but I cannot definitively answer that but there are no doubt several on here who can.